Stem Cells

Hyperbaric Oxygen Therapy for Stem Cells

Stem cells have the remarkable potential to develop into numerous different cell types and serve as the body’s primary internal repair system. The innate ability of stem cells to differentiate into other types of cells with specialized functions (blood, brain, or tissue cells) replenishes and regenerates the body from the effects of aging and disease. Hyperbaric oxygen therapy (HBOT) has been shown to significantly increase the concentration of circulating stem/progenitor cells within the peripheral circulation system. By increasing blood plasma oxygen levels, bone marrow deprived stem cells were shown to significantly proliferate and mobilize. The proposed mechanism of action was through a nitric oxide dependent mechanism. This evidence plays a key role in regenerative medicine as the increased number of stem cells in the body have the ability to provide enhanced and accelerated physiological repair. Studies have demonstrated HBOT’s therapeutic influence on stem cells with the following:

Enhances Stem Cell Activity

Activates Nitric Oxide Synthase Type 3
Proliferates & Mobilizes Bone Marrow Derived Stem Cells
Improves Engraftment & Differentiation of Several Progenitor Cell Types in Organs such as the Spleen, Bone Marrow, Brain, Peripheral Nerve, Pancreas, Cartilage & Heart
Increases in Colony-Forming Cells
Stimulation of Stromal-Derived Growth Factor
Promotion in Endothelial Growth Factor-2 for Angiogenesis
Increases CD34 Expression & Pluripotent Stem Cells